Vaccination against Human Influenza A/H3N2 Virus Prevents the Induction of Heterosubtypic Immunity against Lethal Infection with Avian Influenza A/H5N1 Virus
Identifieur interne : 001022 ( Main/Exploration ); précédent : 001021; suivant : 001023Vaccination against Human Influenza A/H3N2 Virus Prevents the Induction of Heterosubtypic Immunity against Lethal Infection with Avian Influenza A/H5N1 Virus
Auteurs : Rogier Bodewes ; Joost H. C. M. Kreijtz ; Chantal Baas ; Martina M. Geelhoed-Mieras ; Gerrie De Mutsert ; Geert Van Amerongen ; Judith M. A. Van Den Brand ; Ron A. M. Fouchier ; Albert D. M. E. Osterhaus ; Guus F. RimmelzwaanSource :
- PLoS ONE [ 1932-6203 ] ; 2009.
Abstract
Annual vaccination against seasonal influenza viruses is recommended for certain individuals that have a high risk for complications resulting from infection with these viruses. Recently it was recommended in a number of countries including the USA to vaccinate all healthy children between 6 and 59 months of age as well. However, vaccination of immunologically naïve subjects against seasonal influenza may prevent the induction of heterosubtypic immunity against potentially pandemic strains of an alternative subtype, otherwise induced by infection with the seasonal strains.
Here we show in a mouse model that the induction of protective heterosubtypic immunity by infection with a human A/H3N2 influenza virus is prevented by effective vaccination against the A/H3N2 strain. Consequently, vaccinated mice were no longer protected against a lethal infection with an avian A/H5N1 influenza virus. As a result H3N2-vaccinated mice continued to loose body weight after A/H5N1 infection, had 100-fold higher lung virus titers on day 7 post infection and more severe histopathological changes than mice that were not protected by vaccination against A/H3N2 influenza.
The lack of protection correlated with reduced virus-specific CD8+ T cell responses after A/H5N1 virus challenge infection. These findings may have implications for the general recommendation to vaccinate all healthy children against seasonal influenza in the light of the current pandemic threat caused by highly pathogenic avian A/H5N1 influenza viruses.
Url:
DOI: 10.1371/journal.pone.0005538
PubMed: 19440239
PubMed Central: 2678248
Affiliations:
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C. M." last="Kreijtz">Joost H. C. M. Kreijtz</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Baas, Chantal" sort="Baas, Chantal" uniqKey="Baas C" first="Chantal" last="Baas">Chantal Baas</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Geelhoed Mieras, Martina M" sort="Geelhoed Mieras, Martina M" uniqKey="Geelhoed Mieras M" first="Martina M." last="Geelhoed-Mieras">Martina M. Geelhoed-Mieras</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="De Mutsert, Gerrie" sort="De Mutsert, Gerrie" uniqKey="De Mutsert G" first="Gerrie" last="De Mutsert">Gerrie De Mutsert</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Van Den Brand, Judith M A" sort="Van Den Brand, Judith M A" uniqKey="Van Den Brand J" first="Judith M. A." last="Van Den Brand">Judith M. A. Van Den Brand</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title></title><p>Annual vaccination against seasonal influenza viruses is recommended for certain individuals that have a high risk for complications resulting from infection with these viruses. Recently it was recommended in a number of countries including the USA to vaccinate all healthy children between 6 and 59 months of age as well. However, vaccination of immunologically naïve subjects against seasonal influenza may prevent the induction of heterosubtypic immunity against potentially pandemic strains of an alternative subtype, otherwise induced by infection with the seasonal strains.</p></sec><sec><title></title><p>Here we show in a mouse model that the induction of protective heterosubtypic immunity by infection with a human A/H3N2 influenza virus is prevented by effective vaccination against the A/H3N2 strain. Consequently, vaccinated mice were no longer protected against a lethal infection with an avian A/H5N1 influenza virus. As a result H3N2-vaccinated mice continued to loose body weight after A/H5N1 infection, had 100-fold higher lung virus titers on day 7 post infection and more severe histopathological changes than mice that were not protected by vaccination against A/H3N2 influenza.</p></sec><sec><title></title><p>The lack of protection correlated with reduced virus-specific CD8+ T cell responses after A/H5N1 virus challenge infection. These findings may have implications for the general recommendation to vaccinate all healthy children against seasonal influenza in the light of the current pandemic threat caused by highly pathogenic avian A/H5N1 influenza viruses.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Claas, Ec" uniqKey="Claas E">EC Claas</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Van Beek, R" uniqKey="Van Beek R">R van Beek</name></author><author><name sortKey="De Jong, Jc" uniqKey="De Jong J">JC De Jong</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jong, Jc" uniqKey="De Jong J">JC de Jong</name></author><author><name sortKey="Claas, Ec" uniqKey="Claas E">EC Claas</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Lim, Wl" uniqKey="Lim W">WL Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grebe, Km" uniqKey="Grebe K">KM Grebe</name></author><author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name></author><author><name sortKey="Bennink, Jr" uniqKey="Bennink J">JR Bennink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmichael, Aj" uniqKey="Mcmichael A">AJ McMichael</name></author><author><name sortKey="Gotch, Fm" uniqKey="Gotch F">FM Gotch</name></author><author><name sortKey="Noble, Gr" uniqKey="Noble G">GR Noble</name></author><author><name sortKey="Beare, Pa" uniqKey="Beare P">PA Beare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreijtz, Jh" uniqKey="Kreijtz J">JH Kreijtz</name></author><author><name sortKey="De Mutsert, G" uniqKey="De Mutsert G">G de Mutsert</name></author><author><name sortKey="Van Baalen, Ca" uniqKey="Van Baalen C">CA van Baalen</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jameson, J" uniqKey="Jameson J">J Jameson</name></author><author><name sortKey="Cruz, J" uniqKey="Cruz J">J Cruz</name></author><author><name sortKey="Terajima, M" uniqKey="Terajima M">M Terajima</name></author><author><name sortKey="Ennis, Fa" uniqKey="Ennis F">FA Ennis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Ly" uniqKey="Lee L">LY Lee</name></author><author><name sortKey="Ha, Dl" uniqKey="Ha D">DL Ha</name></author><author><name sortKey="Simmons, C" uniqKey="Simmons C">C Simmons</name></author><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name></author><author><name sortKey="Chau, Nv" uniqKey="Chau N">NV Chau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smallman Raynor, M" uniqKey="Smallman Raynor M">M Smallman-Raynor</name></author><author><name sortKey="Cliff, Ad" uniqKey="Cliff A">AD Cliff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neuzil, Km" uniqKey="Neuzil K">KM Neuzil</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Griffin, Mr" uniqKey="Griffin M">MR Griffin</name></author><author><name sortKey="Edwards, Km" uniqKey="Edwards K">KM Edwards</name></author><author><name sortKey="Thompson, Jm" uniqKey="Thompson J">JM Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Izurieta, Hs" uniqKey="Izurieta H">HS Izurieta</name></author><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name></author><author><name sortKey="Kramarz, P" uniqKey="Kramarz P">P Kramarz</name></author><author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name></author><author><name sortKey="Davis, Rl" uniqKey="Davis R">RL Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiore, Ae" uniqKey="Fiore A">AE Fiore</name></author><author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name></author><author><name sortKey="Broder, K" uniqKey="Broder K">K Broder</name></author><author><name sortKey="Iskander, Jk" uniqKey="Iskander J">JK Iskander</name></author><author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Askonas, Ba" uniqKey="Askonas B">BA Askonas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Xs" uniqKey="He X">XS He</name></author><author><name sortKey="Holmes, Th" uniqKey="Holmes T">TH Holmes</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name></author><author><name sortKey="Mahmood, K" uniqKey="Mahmood K">K Mahmood</name></author><author><name sortKey="Kemble, Gw" uniqKey="Kemble G">GW Kemble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schulman, Jl" uniqKey="Schulman J">JL Schulman</name></author><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Neill, E" uniqKey="O Neill E">E O'Neill</name></author><author><name sortKey="Krauss, Sl" uniqKey="Krauss S">SL Krauss</name></author><author><name sortKey="Riberdy, Jm" uniqKey="Riberdy J">JM Riberdy</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Woodland, Dl" uniqKey="Woodland D">DL Woodland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, Sh" uniqKey="Seo S">SH Seo</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, Sh" uniqKey="Seo S">SH Seo</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M Peiris</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, Ma" uniqKey="Williams M">MA Williams</name></author><author><name sortKey="Bevan, Mj" uniqKey="Bevan M">MJ Bevan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belz, Gt" uniqKey="Belz G">GT Belz</name></author><author><name sortKey="Xie, W" uniqKey="Xie W">W Xie</name></author><author><name sortKey="Altman, Jd" uniqKey="Altman J">JD Altman</name></author><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hogan, Rj" uniqKey="Hogan R">RJ Hogan</name></author><author><name sortKey="Usherwood, Ej" uniqKey="Usherwood E">EJ Usherwood</name></author><author><name sortKey="Zhong, W" uniqKey="Zhong W">W Zhong</name></author><author><name sortKey="Roberts, Aa" uniqKey="Roberts A">AA Roberts</name></author><author><name sortKey="Dutton, Rw" uniqKey="Dutton R">RW Dutton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kohlmeier, Je" uniqKey="Kohlmeier J">JE Kohlmeier</name></author><author><name sortKey="Miller, Sc" uniqKey="Miller S">SC Miller</name></author><author><name sortKey="Woodland, Dl" uniqKey="Woodland D">DL Woodland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haanen, Jb" uniqKey="Haanen J">JB Haanen</name></author><author><name sortKey="Toebes, M" uniqKey="Toebes M">M Toebes</name></author><author><name sortKey="Cordaro, Ta" uniqKey="Cordaro T">TA Cordaro</name></author><author><name sortKey="Wolkers, Mc" uniqKey="Wolkers M">MC Wolkers</name></author><author><name sortKey="Kruisbeek, Am" uniqKey="Kruisbeek A">AM Kruisbeek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flynn, Kj" uniqKey="Flynn K">KJ Flynn</name></author><author><name sortKey="Belz, Gt" uniqKey="Belz G">GT Belz</name></author><author><name sortKey="Altman, Jd" uniqKey="Altman J">JD Altman</name></author><author><name sortKey="Ahmed, R" uniqKey="Ahmed R">R Ahmed</name></author><author><name sortKey="Woodland, Dl" uniqKey="Woodland D">DL Woodland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moyron Quiroz, Je" uniqKey="Moyron Quiroz J">JE Moyron-Quiroz</name></author><author><name sortKey="Rangel Moreno, J" uniqKey="Rangel Moreno J">J Rangel-Moreno</name></author><author><name sortKey="Kusser, K" uniqKey="Kusser K">K Kusser</name></author><author><name sortKey="Hartson, L" uniqKey="Hartson L">L Hartson</name></author><author><name sortKey="Sprague, F" uniqKey="Sprague F">F Sprague</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Bree, Gj" uniqKey="De Bree G">GJ de Bree</name></author><author><name sortKey="Van Leeuwen, Em" uniqKey="Van Leeuwen E">EM van Leeuwen</name></author><author><name sortKey="Out, Ta" uniqKey="Out T">TA Out</name></author><author><name sortKey="Jansen, Hm" uniqKey="Jansen H">HM Jansen</name></author><author><name sortKey="Jonkers, Re" uniqKey="Jonkers R">RE Jonkers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name></author><author><name sortKey="Zou, P" uniqKey="Zou P">P Zou</name></author><author><name sortKey="Chen, Yh" uniqKey="Chen Y">YH Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name></author><author><name sortKey="Lo, Cy" uniqKey="Lo C">CY Lo</name></author><author><name sortKey="Misplon, Ja" uniqKey="Misplon J">JA Misplon</name></author><author><name sortKey="Lawson, Cm" uniqKey="Lawson C">CM Lawson</name></author><author><name sortKey="Hendrickson, Ba" uniqKey="Hendrickson B">BA Hendrickson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heikkinen, T" uniqKey="Heikkinen T">T Heikkinen</name></author><author><name sortKey="Booy, R" uniqKey="Booy R">R Booy</name></author><author><name sortKey="Campins, M" uniqKey="Campins M">M Campins</name></author><author><name sortKey="Finn, A" uniqKey="Finn A">A Finn</name></author><author><name sortKey="Olcen, P" uniqKey="Olcen P">P Olcen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luce, Br" uniqKey="Luce B">BR Luce</name></author><author><name sortKey="Nichol, Kl" uniqKey="Nichol K">KL Nichol</name></author><author><name sortKey="Belshe, Rb" uniqKey="Belshe R">RB Belshe</name></author><author><name sortKey="Frick, Kd" uniqKey="Frick K">KD Frick</name></author><author><name sortKey="Li, Sx" uniqKey="Li S">SX Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salo, H" uniqKey="Salo H">H Salo</name></author><author><name sortKey="Kilpi, T" uniqKey="Kilpi T">T Kilpi</name></author><author><name sortKey="Sintonen, H" uniqKey="Sintonen H">H Sintonen</name></author><author><name sortKey="Linna, M" uniqKey="Linna M">M Linna</name></author><author><name sortKey="Peltola, V" uniqKey="Peltola V">V Peltola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ritzwoller, Dp" uniqKey="Ritzwoller D">DP Ritzwoller</name></author><author><name sortKey="Bridges, Cb" uniqKey="Bridges C">CB Bridges</name></author><author><name sortKey="Shetterly, S" uniqKey="Shetterly S">S Shetterly</name></author><author><name sortKey="Yamasaki, K" uniqKey="Yamasaki K">K Yamasaki</name></author><author><name sortKey="Kolczak, M" uniqKey="Kolczak M">M Kolczak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shuler, Cm" uniqKey="Shuler C">CM Shuler</name></author><author><name sortKey="Iwamoto, M" uniqKey="Iwamoto M">M Iwamoto</name></author><author><name sortKey="Bridges, Cb" uniqKey="Bridges C">CB Bridges</name></author><author><name sortKey="Marin, M" uniqKey="Marin M">M Marin</name></author><author><name sortKey="Neeman, R" uniqKey="Neeman R">R Neeman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zangwill, Km" uniqKey="Zangwill K">KM Zangwill</name></author><author><name sortKey="Belshe, Rb" uniqKey="Belshe R">RB Belshe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vesikari, T" uniqKey="Vesikari T">T Vesikari</name></author><author><name sortKey="Karvonen, A" uniqKey="Karvonen A">A Karvonen</name></author><author><name sortKey="Pellegrini, M" uniqKey="Pellegrini M">M Pellegrini</name></author><author><name sortKey="Borkowski, A" uniqKey="Borkowski A">A Borkowski</name></author><author><name sortKey="Groth, N" uniqKey="Groth N">N Groth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cassetti, Mc" uniqKey="Cassetti M">MC Cassetti</name></author><author><name sortKey="Couch, R" uniqKey="Couch R">R Couch</name></author><author><name sortKey="Wood, J" uniqKey="Wood J">J Wood</name></author><author><name sortKey="Pervikov, Y" uniqKey="Pervikov Y">Y Pervikov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Girard, Mp" uniqKey="Girard M">MP Girard</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Pervikov, Y" uniqKey="Pervikov Y">Y Pervikov</name></author><author><name sortKey="Palkonyay, L" uniqKey="Palkonyay L">L Palkonyay</name></author><author><name sortKey="Kieny, Mp" uniqKey="Kieny M">MP Kieny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Baars, M" uniqKey="Baars M">M Baars</name></author><author><name sortKey="Claas, Ec" uniqKey="Claas E">EC Claas</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="Spronken, Mi" uniqKey="Spronken M">MI Spronken</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Baas, C" uniqKey="Baas C">C Baas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palmer, D" uniqKey="Palmer D">D Palmer</name></author><author><name sortKey="Dowle, W" uniqKey="Dowle W">W Dowle</name></author><author><name sortKey="Coleman, M" uniqKey="Coleman M">M Coleman</name></author><author><name sortKey="Schild, G" uniqKey="Schild G">G Schild</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frank, Al" uniqKey="Frank A">AL Frank</name></author><author><name sortKey="Puck, J" uniqKey="Puck J">J Puck</name></author><author><name sortKey="Hughes, Bj" uniqKey="Hughes B">BJ Hughes</name></author><author><name sortKey="Cate, Tr" uniqKey="Cate T">TR Cate</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voeten, Jt" uniqKey="Voeten J">JT Voeten</name></author><author><name sortKey="Brands, R" uniqKey="Brands R">R Brands</name></author><author><name sortKey="Palache, Am" uniqKey="Palache A">AM Palache</name></author><author><name sortKey="Van Scharrenburg, Gj" uniqKey="Van Scharrenburg G">GJ van Scharrenburg</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Philippa, J" uniqKey="Philippa J">J Philippa</name></author><author><name sortKey="Baas, C" uniqKey="Baas C">C Baas</name></author><author><name sortKey="Beyer, W" uniqKey="Beyer W">W Beyer</name></author><author><name sortKey="Bestebroer, T" uniqKey="Bestebroer T">T Bestebroer</name></author><author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karber, G" uniqKey="Karber G">G Karber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreijtz, Jh" uniqKey="Kreijtz J">JH Kreijtz</name></author><author><name sortKey="Bodewes, R" uniqKey="Bodewes R">R Bodewes</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G van Amerongen</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name></author><author><name sortKey="Biddison, We" uniqKey="Biddison W">WE Biddison</name></author><author><name sortKey="Bennink, Jr" uniqKey="Bennink J">JR 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uniqKey="De Mutsert G" first="Gerrie" last="De Mutsert">Gerrie De Mutsert</name><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><name sortKey="Geelhoed Mieras, Martina M" sort="Geelhoed Mieras, Martina M" uniqKey="Geelhoed Mieras M" first="Martina M." last="Geelhoed-Mieras">Martina M. Geelhoed-Mieras</name><name sortKey="Kreijtz, Joost H C M" sort="Kreijtz, Joost H C M" uniqKey="Kreijtz J" first="Joost H. C. M." last="Kreijtz">Joost H. C. M. Kreijtz</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name><name sortKey="Van Den Brand, Judith M A" sort="Van Den Brand, Judith M A" uniqKey="Van Den Brand J" first="Judith M. A." last="Van Den Brand">Judith M. A. 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